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Withdraw Determination of the Median Effective Dose (ED50) of Propofol Combined with Low-dose Oliceridine in Painless Hysteroscopy Using the Modified Sequential Method

Determination of the Median Effective Dose (ED50) of Propofol Combined with Low-dose Oliceridine in Painless Hysteroscopy Using the Modified Sequential Method

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104056
Enrollment
Unknown
Registered
2025-06-10
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Painless Hysteroscopy

Interventions

Group 1:Oliceridine 0.02mg/kg
Group 2:Oliceridine 0.03mg/kg

Sponsors

Department of Anesthesiology, Cixi People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients with elective painless hysteroscoy, ASA I-II grade; 2. Aged 18-60 years; 3. BMI 18-25 kg/m^2; 4. Communication is normal; 5. Voluntarily test and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe respiratory and circulatory system diseases: such as severe coronary heart disease, chronic obstructive pulmonary disease, etc.; 2. Endocrine system diseases: such as pituitary tumor, severe diabetes, hypercortisol syndrome, pheochromocytoma, etc.; 3. Mental and psychological diseases: such as schizophrenia, depression, history of chronic analgesic drug use, history of alcoholism, opioid dependence; 4. History of allergy to anesthetics.

Design outcomes

Primary

MeasureTime frame
Median effective dose;Adverse effect;

Secondary

MeasureTime frame
Dosage of Propofol;Duration time given initial dose of Propofol;Inspection time;Awake time;Recovery time;MAP/HR before induction;MAP/HR at beginning of operation;MAP/HR at the end of operation;MAP/HR at the time of opening eye;

Countries

China

Contacts

Public ContactChen Siyu

Cixi People's Hospital

csy0410@126.com+86 152 2555 0982

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026