Treatment-resistant Depression
Conditions
Interventions
TRD group:Maintenance of the original drug regimen combined with PET/MRI-guided transcranial magnetic stimulation therapy
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Signed a written informed consent, willing to participate in the study and be evaluated; 2. This episode met DSM-5 diagnostic criteria for major depression without psychotic symptoms. 3. 18 to 45 years old, gender is not limited; 4. Right-handedness. 5. Han Chinese. 6. Receive two or more adequate doses and courses of antidepressant drugs in different mechanisms that were not effective and had been stable for more than 7. weeks on antidepressant medication prior to enrollment, with non-responsiveness defined as a decrease in HAMD-24 score of = 20; 8. Visual acuity was normal or corrected to normal (>= 1.0), and all had an educational background of junior high school or higher; 9. Ability to complete spatial suppression psychophysical experiment.
Exclusion criteria
Exclusion criteria: 1.Patients with epilepsy, patients with metal objects in their bodies and patients with acute cerebrovascular accidents; 2.Patients with organic mental disorders and mental retardation; 3.Pregnant and lactating women; 4.Presence of serious suicidal behaviour or ideation; 5.Patients with metallic objects in the body or other contraindications to PET/MRI scanning; 6.Benzodiazepines were taken during the experimental period (iin 12 hours).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in synaptic density after treatment;Change in Suppression Index after treatment;Hamilton Depression Scale (24-items) Total Score Change; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the rate of Hamilton Anxiety Scale score;Change in the rate of Beck Scale of Suicidal Ideation score;the Snaith-Hamilton Pleasure Scale;Change in electroencephalogram;Change in the Laukes Emotional Intensity Scale score;Change in the score of Visual Analog Scale (VAS);Change in the score of THINC-it; | — |
Countries
China
Contacts
Public ContactManli Huang
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed