Postoperative delirium
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Meet the surgical indications and plan to undergo hip replacement surgery; 2. Age: 18-90 years old; 3. ASA level 1-3; 4. Clearly understand, voluntarily participate in the study, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are known to be allergic to sugammadex sodium and neostigmine components; 2. There is abuse of psychotropic substances or alcohol; 3. Patients who cannot tolerate various adverse reactions of sugammadex sodium and neostigmine; 4. Merge severe cardiovascular and cerebrovascular diseases, respiratory system diseases, and severe immune system diseases, severe liver dysfunction, renal dysfunction; 5. A score of<15 on the Mini Mental State Examination (MMSE), combined with severe psychological disorders, cognitive impairment, any psychiatric disorders, skull or scalp injuries; 6. Visual or hearing impairment, communication difficulties; 7. Patients expected to enter the ICU 8. Other situations where the researcher deems it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 3 days after surgery;Number of postoperative delirium episodes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score at 2 hours after surgery;Anxiety score at 1 day after surgery;Depression score at 1 day after surgery;From the end of anesthesia to the time of extubation;Delayed extubation;PACU time;The number of scores of MMSE 3 days after surgey;The time of TOFr recovered to 0.9;Subtypes of delirium;Time to first appearance of T2;TOFr at extubation;Incidence of SpO2<95% after surgery;Incidence of SpO2<90% after surgery;WBC count after surgery;NE count after surgery;ALT count after surgery;AST count after surgery;Albumin count after surgery;Glucose count after surgery;Scr count after surgery;Changes in heart rate before and after medication;Changes in blood pressure before and after medication;Time to first ventilation;Time to first defecation;Time to first off-bed activities;Length of hospital stay;Pain score at 24 hours after surgery;Pain score at 48 hours after surgery;Pain score at 72 hours after surgery;Anxiety score at 3 days after surgery;Depression score at 3 days after surgery; | — |
Countries
China
Contacts
Public ContactYang Chun
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed