None
Conditions
Interventions
Research Group (Group A):Sufentanil is routinely administered as the standard analgesic during anesthesia induction.
Control Group (Group B):Oliceridine is administered as the analgesic during anesthesia induction.
Sponsors
Deyang People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients assessed by physicians as unable to tolerate the pain stimuli of the surgical procedure and requiring hysteroscopic surgery under laryngeal mask airway (LMA) general anesthesia; 2.Aged 18-65 years; 3.ASA physical status classification I-III; 4.Voluntarily participate in the trial and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients classified as ASA physical status IV or higher (indicating severe systemic disease with functional disability, including but not limited to: cardiac function NYHA class III or higher, myocardial ischemia, severely reduced cardiac ejection fraction, third-degree atrioventricular block, stage 3 hypertension, respiratory failure, severe COPD, significantly impaired pulmonary function, decompensated hepatic/renal dysfunction); 2.Known hypersensitivity to trial drug components or contraindications to the study medications; 3.Subjects with compromised cooperation capacity (e.g., psychiatric disorders, anticipated neuropsychological evaluation difficulties, communication barriers due to speech/dialect issues); 4. History of alcohol or substance abuse; 5. Current participation or participation in other clinical trials within 12 weeks prior to this trial; 6.Morbid obesity (BMI >30 kg/m²); 7.Inability to comprehend the study procedures or decline participation; 8.Deemed medically unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes during induction;Time to emergence and extubation postoperatively;Total intraoperative opioid consumption and number of supplemental opioid administrations;Post-extubation Visual Analog Scale (VAS) pain score;The proportion of patients requiring intraoperative vasoactive agents;Adverse events within 24 hours postoperatively;The incidence of respiratory depression in the post-anesthesia care unit (PACU); | — |
Countries
China
Contacts
Public ContactJia Han
Deyang People's Hospital
Outcome results
None listed