Thyroid cancer
Conditions
Interventions
Group E1:Esketamine 0.4mg/kg intravenously is given at the time of anesthesia induction
Group E2:Esketamine 0.8mg/kg nasal drops were given at the time of anesthesia induction
Group C:Intravenous injection of the same amount of normal saline at the time of anesthesia induction
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-65 years; (2) Deviation from ideal body weight <= 25%; (3) American Society of Anesthesiologists ASA I - II; (4) Duration of surgery less than 3 hours for thyroid surgery patients; (5) No history of long-term use of analgesics, sedatives, or anxiolytics;
Exclusion criteria
Exclusion criteria: (1) Patients with known allergy to esketamine; Patients at severe risk of elevated blood pressure or intracranial pressure; Patients with known allergies to midazolam or benzodiazepines, acute closed-eye glaucoma, or open-angle glaucoma without effective treatment; (2) Body weight exceeds the ideal body weight by +/-25%; (3) Patients with any serious systemic organ disease (cardiopulmonary/kidney/liver), neurological disease (cerebral palsy, autism, etc.), or combined use of anesthetics or other central nervous system inhibitors; (4) Patients who have taken any drug that may interfere with the pharmacokinetics or pharmacodynamics of midazolam, such as antifungals, macrolide antibiotics, cimetidine, rifamycin, or calcium channel blockers; (5) Patients with communication disorders, cognitive dysfunction, and a history of mental illness;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOR-15 scale for quality of recovery score at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, blood oxygen saturation, and blood pressure before oral midazolam, 10 min, 20 min after taking the drug, and before anesthesia induction;Visual Analogue Scale (VAS) score for pain at 6, 12, 24h postoperatively;Patient's sleep on the first night after surgery (Athens Insomnia Scale AIS);Hospital Anxiety and Depression Scale (HADS) 24 hours postoperatively;The amount of anesthetic used: sedatives such as propofol, and the amount of analgesics such as sufentanil and remifentanil;Nausea, vomiting, delirium and other adverse events occurred within 24 hours after surgery;Anxiety Visual Analogue Scale (VAS-A) and Ramsay score before oral midazolam, 10 min and 20 min after taking the drug, and before anesthesia induction; | — |
Countries
China
Contacts
Public ContactGuanghong Xu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed