Lung injury with one-lung ventilation during lobectomy
Conditions
Interventions
Control group:Nebulization was performed on the healthy side
Experimental group:Nebulization was performed on the affected side
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists grade 2-3; 2.Without preoperative radiotherapy, chemotherapy and hormone therapy; 3.No obvious abnormal liver and kidney function; 4.New York Heart Association functional class ?-?, with normal heart rhythm; 5.No pulmonary infection before operation or more than 1 week after the infection was cured; 6.Normal pulmonary function or mild ventilatory dysfunction; 7.Patients with fully autonomous decision-making ability who plan to undergo thoracoscopic lobectomy;
Exclusion criteria
Exclusion criteria: 1.Patients with diabetes, hypertension and other chronic diseases without standardized treatment; 2.Atrioventricular block, left and right bundle branch conduction abnormalities or sick sinus syndrome; 3.Patients who have experienced hemoptysis more than three times (with each episode exceeding 5mL); 4.Patients with asthma or chronic bronchitis; 5.Patients with Type I or II respiratory failure; 6.Patients requiring thoracotomy for surgical purposes; 7.Patients with a surgical duration exceeding 3.5 hours; 8.Patients suspected of having a drug allergy; 9.Patients receiving atropine, ephedrine, or esmolol more than twice during nebulization inhalation; 10.Those who refuse to participate in this project or withdraw halfway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of oxygenation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Inflammatory factor;Hemodynamic indicators; | — |
Countries
China
Contacts
Public ContactQu Liangchao
The First Affiliated Hospital of Nanchang University
Outcome results
None listed