Post-refractive Surgery Dry Eye
Conditions
Interventions
treatment group:Treatment group received an instillation of 0.05% cyclosporine A eyedrops (GYZZ H20203239, Shenyang Xingqi Pharmaceutical Co Ltd.) twice a day, 20% Deproteinized Calf Blood Extract Eye
control group:20% Deproteinized Calf Blood Extract Eye Gel (Cycloome, SHENYANG XINGQI Pharmaceutical Co., China) before bedtime and 3% Diquafosol Sodium Eye Drops (Santen Pharmaceutical Co., Japan) th
Sponsors
the Second Affiliated Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: a. Aged between 20 and 50 years, regardless of gender. b. Underwent bilateral refractive laser surgery to the cornea within 1 to 3 months prior to enrollment, and had not been diagnosed with DES prior to the procedure. c. Meet the diagnostic criteria for post-keratorefractive surgery dry eye syndrome as outlined in the 2021 Chinese Medical Association Ophthalmology Branch Cornea and Dry Eye Group's "Chinese Expert Consensus on Dry Eye Associated with Corneal Refractive Surgery (2021)".
Exclusion criteria
Exclusion criteria: Exclusion Criteria: a. Individuals with a history or current condition of severe clinical diseases in the circulatory system, endocrine system, nervous system, digestive system, respiratory system, hematology, immunology, psychiatry, or metabolic disorders, or any other condition that could interfere with the results of the study; b. Patients with active ocular infections or ongoing inflammatory therapy; c. Patients with an allergy to any of the drug components used in the study; d. Patients with permanent occlusion of the tear ducts or other anatomical abnormalities affecting tear secretion; e. Pregnant and lactating women; f. Patients with severe psychological or cognitive impairments that prevent them from understanding the study requirements or providing informed consent; g. Individuals who may not be able to complete the project for other reasons, or who the project personnel consider should not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OSDI score, Ocular Surface Disease Index;pentacam;visual quality score;dry eye examination; | — |
Countries
China
Contacts
Public ContactHan Wei
the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China
Outcome results
None listed