Depressed
Conditions
Interventions
Esketamine (Group E):Anesthesia induction using intravenous injection of esketamine (0.5mg/kg) and succinylcholine chloride (1mg/kg)
Propofol group (P group):Anesthesia induction using intravenous injection of propofol (1.5-2.0mg/kg) and succinylcholine chloride (1mg/kg)
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Meet the 24-item Hamilton Depression Rating Scale (HAMD-24) score >=20 points; Ability to cooperate with doctors to complete all scale assessments and correctly understand the assessment contents; The person or the client agrees to participate in the study and sign the informed consent form; Magnetic shock therapy is proposed.
Exclusion criteria
Exclusion criteria: 1. Cerebrovascular malformation, aneurysm, hypertension or glaucoma; 2. ASA score of IV or V; 3. Complications such as respiratory diseases, cardiovascular diseases, intracranial hypertension, cerebrovascular diseases, etc.; 4. Presence of foreign bodies, such as pacemakers, intracranial electrodes; 5. History of epilepsy; 6. History of drug abuse; 7. Concomitant mental disorders; 8. Pregnancy; 9. History of serious adverse reactions related to anesthetics; 10. Refusal to accept the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HDRS);Seizure energy index;Duration of epilepsy;Total MST times;MST setting frequency;MST stimulation intensity;MST stimulation time;Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Blood oxygen saturation; | — |
Countries
China
Contacts
Public ContactLi rui;Geng fen
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed