Pulmonary hemorrhage in preterm infants
Conditions
Interventions
HFOV Group:High-frequency oscillatory ventilation (HFOV) therapy, with parameter settings as follows: initial mean airway pressure (MAP) set at 2 cmH2O higher than the previous CMV value, frequency 10
parameters were dynamically adjusted based on oxygenation index (OI), SpO2, and PaCO2, with endotracheal bleeding assessed every 6 hours.
CMV Group:Gradually increase PEEP (1 cmH?O each time) and simultaneously adjust PIP/PS to ensure tidal volume. Dynamically adjust parameters based on the oxygenation index (OI), SpO2, and PaCO2. Asses
Sponsors
West China Second University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Preterm infants, defined as gestational age < 37 weeks. 2.Requirement for invasive mechanical ventilation. 3.Clinical diagnosis of pulmonary hemorrhage, excluding bloody tracheal secretions caused by endotracheal tube injury or other traumatic etiologies.
Exclusion criteria
Exclusion criteria: 1.Use of HFV (High-Frequency Ventilation) prior to the onset of pulmonary hemorrhage. 2.Presence of severe congenital malformations, chromosomal abnormalities, or other primary pulmonary diseases (e.g., congenital diaphragmatic hernia). 3.Patients diagnosed with Grade 3/4 intraventricular hemorrhage (IVH) before the occurrence of pulmonary hemorrhage. 4.Patients whose legal guardians refuse to provide consent for trial participation will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation Index ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of pulmonary hemorrhage;Duration of mechanical ventilation;Pulmonary air leak syndrome;Bronchopulmonary dysplasia (BPD);Mortality;Grade 3/4 intraventricular hemorrhage (IVH);Periventricular leukomalacia (PVL); | — |
Countries
China
Contacts
Public ContactWang Hua
West China Second University Hospital
Outcome results
None listed