Severe pneumonia
Conditions
Interventions
Sponsors
The Affiliated Hospital of Jining Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with a clear diagnosis of severe pneumonia who have undergone endotracheal intubation and invasive mechanical ventilation. 2. Patients with a definite improvement in the primary disease that led to respiratory failure, and who are to be evacuated from mechanical ventilation and removed from the endotracheal intubation. 3. Meet the weaning criteria of the "Guidelines for the Clinical Application of Mechanical Ventilation" of the Critical Care Medicine Branch of the Chinese Medical Association, such as: oxygenation index: PaO2/FiO2>=150 to 300 mmHg; PEEP = 7.25, and for COPD: pH > 7.30, FiO2 50 mmHg. Hemodynamically stable, no dynamic changes in myocardial ischemia, no obvious clinical hypotension (no vasoactive drug treatment or only small doses of drugs, such as dopamine or dobutamine <5~10µg/kg/min). 4. Patients who are to be sedated with remimazolam tosylate or dexmedetomidine during weaning.
Exclusion criteria
Exclusion criteria: 1. Age> 80 years old or 35; 3. Pregnant and lactating women; 4. Patients with severe hepatic and renal insufficiency; 5. New York class of cardiac function grade IV; 6. Patients who are not using remimazolam tosylate or dexmedetomidine or concomitantly; 7. Refusal of the patient or his/her agent to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Satisfaction rate of sedation; | — |
Countries
China
Contacts
Public ContactXie Xuemeng
The Affiliated Hospital of Jining Medical College
Outcome results
None listed