Coronary heart disease
Conditions
Interventions
CPET group:Power Cycling Exercise Styles
Prospective cohort of patients with ACS:None
Control group:None
Sponsors
Tibet Autonomous Region People's Hospital/Tibet High Altitude Medical Research Institute
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Screening and establishment of risk factors and clinical phenotype characteristics of ACS at different altitudes in plateau areas Inclusion criteria: 1) Patients diagnosed with acute coronary syndrome (ACS), including acute ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina. 2) Age over 18, no gender restriction. 3) Voluntary participation in the study and signing of the informed consent form. (2) 1. Dual antiplatelet therapy research for acute coronary syndrome in plateau areas and evaluation of bleeding and thrombosis risks in dual antiplatelet therapy for ACS in plateau areas: Based on clinical indicators such as CRUSADE score, PRECISE-DAPT score, ACUITY score, Barc bleeding score, platelet activity, and coagulation function, assess the bleeding risk of dual antiplatelet therapy. Use machine learning and other methods to optimize the risk assessment model for dual antiplatelet therapy under plateau conditions. Inclusion criteria: Meet the diagnostic criteria for acute coronary syndrome (ACS) (STEMI, NSTEMI, unstable angina). Age =18 years, no gender restrictions, sign informed consent forms, and have resided long-term in plateau areas (altitude =2500 meters) or relocated for more than six months. (3) 2. Post-PCI cardiac rehabilitation guidance plan: Inclusion criteria: 1) Coronary heart disease diagnosis confirmed, with at least one vessel lesion >50% stenosis; 2) No new myocardial infarction in the past three months; 3) Post-PCI, NYHA class I and II heart function; 4) Stable clinical symptoms and undergoing standardized coronary heart disease drug treatment; 5) Basic reading and communication ability; 6) Willing to participate in this study and provide informed consent; 7) Age 18-65 years, no gender restrictions. (4) Construction of a hierarchical diagnosis and treatment collaborative management model suitable for plateau environments for acute coronary syndrome and assessment of its practicality and promotion value. Inclusion criteria: Meet the diagnostic criteria for acute coronary syndrome (ACS). Age =18 years, voluntary participation in the study and signing of the informed consent form. Long-term residence or relocation exceeding six months in plateau areas (altitude =2500 meters).
Exclusion criteria
Exclusion criteria: (i) Screening and establishment of ACS risk factors and clinical phenotype characterisation at different altitudes in highland areas Exclusion criteria: ? Previous severe other cardiovascular diseases (such as heart valve disease, cardiomyopathy, congenital heart disease and other known history of cardiovascular disease).? Combined severe infectious diseases or malignant tumours with expected survival of less than 6 months.(iii) Serious organ failure (e.g. liver and kidney insufficiency). (ii) 1. Research on dual-antibiotic therapy for acute coronary syndrome in plateau area and assessment of bleeding risk and thrombosis risk of dual-antibiotic therapy for ACS in plateau area: Based on clinical indicators such as CRUSADE score, PRECISE-DAPT score, ACUITY score, Barc Bleeding Score, platelet activity, coagulation function and other clinical indicators, the bleeding risk of dual-antibiotic therapy is assessed.Optimise the risk assessment model of dual-antibiotic therapy in the plateau setting using machine learning and other methods. Exclusion criteria: comorbid serious non-cardiovascular diseases (e.g. malignancy, end-stage hepatic and renal insufficiency).Lack of key clinical information during data collection or poor adherence to follow-up.Those who have received other interventional studies affecting the study results. (iii), 2. Post-PCI cardiac rehabilitation guideline programme: Exclusion criteria: ? Presence of cardiac diseases other than coronary artery disease, including congenital heart disease, valvular disease, hypertrophic cardiomyopathy, severe pulmonary hypertension, etc.; ? Those with known relative and absolute contraindications to CPET; ? Those with recent traumatic injuries or surgeries and exercise limitation; ? Combination of cerebrovascular disease, hepatic and renal insufficiency, and chronic lung disease. (iv) Construct a collaborative management model for graded diagnosis and treatment of acute coronary syndrome applicable to the plateau environment, and evaluate its practicality and promotion value. Exclusion Criteria: Patients with expected survival of less than 6 months or with serious complications (e.g. malignant tumours).Lack of key clinical information (e.g., imaging data, laboratory data) during data collection.Patients refused or withdrew from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| partial pressure of oxygen;blood pressure;ambulatory blood pressure;SPO2;BMI;routine blood test;liver and kidney function;cTn;NT-proBNP;inflammation marker;electrocardiography;echocardiography; | — |
Secondary
| Measure | Time frame |
|---|---|
| altitude;pneumatic;temperature; | — |
Countries
China
Contacts
Public ContactKelsang Norbu
Tibet Autonomous Region People's Hospital
Outcome results
None listed