Psoriasis
Conditions
Interventions
The gusucilumab group:NA
Sponsors
West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age >=18 years old. (2) Patients diagnosed with moderate to severe plaque psoriasis, with PASI >=3 or BSA >=3%. (3) At baseline, the patient presented with entheseal inflammation or synovitis on imaging, with or without joint pain. (4) The patient has received gusucilumab treatment since March 2023 or has been using gusucilumab since enrollment. (5) Willing and able to provide informed consent.
Exclusion criteria
Exclusion criteria: (1) Previously or at the time of enrollment, diagnosed with PsA according to the CASPAR classification criteria. (2) Previously or at the time of enrollment, diagnosed with any other clinical arthritis, including rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis, etc. (3) Previous use of biological agents or small molecule targeted drugs. (4) The patient has severe active infections, untreated latent tuberculosis or malignant tumors and other contraindications for the use of biological agents. (5) The patient is in a pregnant state. (6) Key retrospective data were lacking, such as: ultrasound examination results at baseline and follow-up, PASI, BSA, VAS score for joint pain, etc. (7) The patient withdraws halfway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Musculoskeletal Power Doppler Ultrasound Composite Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Psoriasis Area and Severity Index, PASI;Body Surface Area, BSA;modified Nail Psoriasis Severity Index, mNAPSI;Functional Assessment of Chronic Illness Therapy-Fatigue,FACIT-F;Dermatology Life Quality Index,??DLQI;Location of joint pain;Duration of joint pain;VAS for joint pain;Blood routine;Urine routine;Fecal routine;biochemical test;CRP;ESR;Chest CT;Color Doppler ultrasound for liver cirrhosis/liver fibrosis;Adverse event record; | — |
Countries
China
Contacts
Public ContactLi Wei
Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, China
Outcome results
None listed