Systemic inflammatory response
Conditions
Interventions
Dexamethasone group:Administer 10mg of dexamethasone via intravenous drip
Utesitide group:The Utesitide group received 50,000 IU/h of Utesitide through infusion
Combined medication group:Simultaneously administer 10mg of dexamethasone via intravenous drip and 50,000 IU/h of ulinastatin through infusion pump
Sponsors
Leshan People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, gender is not limited; 2. Diagnosed with upper urinary tract stones, and in line with the surgical indications for endoluminal holmium laser lithotripsy; 3. No systemic infection or severe inflammatory reaction (such as fever, significant increase in white blood cell count, etc.) before surgery; 4. No serious heart, liver and kidney insufficiency; 5. Voluntarily sign the informed consent form and be able to cooperate with the postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1. Systemic infection or active inflammation (such as fever, significantly elevated white blood cell count) before surgery; 2. Known hypersensitivity to dexamethasone, ulinastatin or their components; 3. Recent (within 3 months) use of glucocorticoids or immunosuppressants; 4. Combined with malignant tumors, immune system diseases or hematologic diseases; 5. Pregnant or lactating females; 6. Those who are unable to cooperate with treatment or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| white blood cell;Calcitonin;C-reactive protein;Interleukin-6; | — |
Countries
China
Contacts
Public ContactZhang Mingmin
Leshan People's Hospital
Outcome results
None listed