Postoperative delirium (POD)
Conditions
Interventions
Control group:Except for high fascia iliaca block, it is the same as experimental group.
Experimental group:Before surgery, ultrasound-guided high fascia iliaca block was performed with 0.33% ropivacaine, and after the block took effect, in order: 0.2mg/kg cis-atracurium, 0.2mg/kg etomida
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2.American Society of Anesthesiologists (ASA) classification I-III; 3.Preoperative Mini-Mental State Examination (MMSE) score >= 24, with no language communication; 4. Educational level sufficient to complete preoperative cognitive function tests; 5. Surgical duration < 3 hours.
Exclusion criteria
Exclusion criteria: 1. Suffering from neuropsychiatric disorders; 2.Attention deficit disorder; 3. Dysfunction of major organs, combined with ischemic cardiomyopathy or adrenal cortical insufficiency; 4. Long-term use of psychotropic drugs, steroids, or anticholinergic drugs; 5.History of severe hearing or visual impairment; 6. Severe preoperative anxiety requiring sedatives; 7. History of allergy to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The dosage of opioid use during the perioperative period.;Changes in serum IL-6 and TNF-a levels before and after surgery;The CAM-CR delirium scale scores at 24, 48, and 72 hours postoperatively in both patient groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other perioperative parameters; | — |
Countries
China
Contacts
Public ContactWen Chao
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed