Acute postoperative pain
Conditions
Interventions
Experimental Group 1:Induction phase: intravenous injection of esketamine 0.25mg/kg (diluted to 10ml with normal saline). Paravertebral block medication: liposomal bupivacaine 3mg/kg (diluted to 35ml
Experimental Group 2:Induction phase: intravenous injection of 10ml normal saline. Paravertebral block medication: liposomal bupivacaine 3mg/kg (diluted to 35ml with normal saline, 25ml injected into
Control Group:Induction phase: intravenous injection of 10ml normal saline. No paravertebral block will be performed.
Sponsors
General Hospital of the Northern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 to 75 years old, inclusive; 2.Surgical Plan: Scheduled for elective thoracoscopic thoracic surgery under general anesthesia with double-lumen endotracheal intubation; 3.Body Mass Index (BMI): 18 to 30 kg/m²; 4.ASA Physical Status Classification: Grade I to III (as defined by the American Society of Anesthesiologists). Informed Consent; 5.Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Known allergy to the active ingredients or excipients of esketamine or long-acting local anesthetics; 2.Coagulation disorders or poorly controlled diabetes mellitus; 3.Patients with severe disturbance of consciousness, or a history of psychiatric disorders (schizophrenia, mania, bipolar disorder, confusion, etc.), or cognitive dysfunction; 4.Chronic drug abusers; patients with a history of sedative/anesthetic drug use within the past month; 5.Patients with abnormal preoperative physical examination findings (e.g., thoracic vertebral trauma, surgical history, scoliosis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative opioid consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score;Postoperative patient-controlled analgesia (PCA) activation times;Postoperative quality of recovery;Intraoperative bradycardia incidence;Intraoperative hypotension incidence;Intraoperative hypertension incidence;Intraoperative hemodynamic fluctuations;Postoperative nausea and vomiting (PONV) incidence;Postoperative pruritus incidence;Postoperative dizziness incidence;Postoperative respiratory depression incidence;Postoperative local anesthetic toxicity incidence;Postoperative nerve injury incidence;Postoperative hypotension incidence;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactJing Li
General Hospital of Northern Theater Command
Outcome results
None listed