chronic nonspecific low back pain
Conditions
Interventions
Intervention Group A:Repetitive transcranial magnetic stimulation (rTMS) will be administered to the left dorsolateral prefrontal cortex (DLPFC) at a frequency of 10 Hz. The stimulation intensity is s
Intervention Group B:Repetitive transcranial magnetic stimulation (rTMS) will be administered to the motor cortex at a frequency of 20 Hz. The stimulation intensity is set at 95% of the resting motor
Control group C:Sham repetitive transcranial magnetic stimulation (rTMS) will be administered with the coil positioned perpendicular to the skull to prevent neural stimulation effects. The stimulation
Sponsors
Tai 'an City Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 18-50 years old who have been clinically diagnosed with chronic nonspecific low back pain by a physician; (2) Patients with a chronic course of nonspecific low back pain exceeding 6 months, and with a Visual Analogue Scale (VAS) score >=4 or an Oswestry Disability Index (ODI) score >=8 over the past two weeks; (3) Voluntarily signed the informed consent form; (4) Right-handed.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of rTMS treatment, contraindications to rTMS (e.g., those with implanted metal devices, personal or family history of epilepsy, structural brain lesions), or other conditions unsuitable for rTMS therapy; (2) Patients with other somatic conditions causing moderate or severe pain (e.g., post-stroke neuropathic pain, fibromyalgia, or osteoarthritis) or those who have undergone major surgery (e.g., joint replacement) within the past 6 months; (3) Patients with severe psychiatric or neurological disorders (e.g., major depressive disorder, bipolar disorder) or other significant somatic diseases (e.g., hepatic/renal failure, malignancy); (4) Patients who have taken medications (other than analgesics) that may interfere with experimental outcomes within the last 3 months (e.g., anticonvulsants, antidepressants, or antiepileptic drugs); (5) Patients with substance or alcohol addiction; (6) Pregnant women or females planning pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oswestry Disability Index;Visual Analogue Scale, VAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Central Sensitization Inventory;Quantitative sensory testing;Insomnia Severity Index;7-item Generalized Anxiety Disorder Questionnaire;Patient Health Questionnaire - 9 items; | — |
Countries
China
Contacts
Public ContactYang Wenrong
Tai 'an City Central Hospital
Outcome results
None listed