Gastrointestinal Endoscopy
Conditions
Interventions
Experimental group:Administer 0.25 mg/kg ciprofol combined with 0.02mg/kg Oliceridine for sedation induction(The weight in kilograms is the fat free weight), and proceed with gastroscopy only when the
Control group:Administer 0.25 mg/kg ciprofol combined with 0.1 µg/kg sufentanil for sedation induction(The weight in kilograms is the fat free weight), and proceed with gastroscopy only when the patie
Sponsors
Jinjiang Municipal Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 60-80 years (inclusive); 2.American Society of Anesthesiologists (ASA) Physical Status Classification I-III; 3.Patients planning to undergo painless gastroscopy in our hospital; 4.Voluntarily enrolled in the study and provided written informed consent.
Exclusion criteria
Exclusion criteria: 1.Allergy or contraindications to the anesthetic agents planned for use; 2.Patients with anticipated difficult airway, history of obstructive sleep apnea (OSA), gastrointestinal obstruction, or prolonged Q-T interval; 3.History of psychiatric disorders, chronic use of psychotropic agents, sedatives, benzodiazepines, or CYP2D6 inducers/inhibitors (e.g., paroxetine hydrochloride, mebhydrolin napadisylate); 4.Cognitive impairment rendering patients unable to comply with study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia in patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP;HR;RR;PETCO2;Respiratory depression;VAS score;Incidence of PONV;Total dose of Ciprofol;Patient satisfaction;Apnea; | — |
Countries
China
Contacts
Public ContactPeixi Yan
Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian Hospital)
Outcome results
None listed