Aging
Conditions
Interventions
Sodium bicarbonate group:Oral administration of alkaline water containing sodium bicarbonate
Control group:Oral administration of neutral water without sodium bicarbonate
Sponsors
Xiangtan First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Basic selection conditions Demographic indicators Age: 18~60 years old (including boundary value) Gender: unlimited (gender distribution needs to be recorded, and the final enrollment needs to meet the sex ratio of 1:1 between the experimental group and the control group) BMI: 18.5 = 130 g/L for men and > = 120 g/L for women White blood cell count: (4~10)×10^9/L Fasting blood glucose: 3.9~6.1 mmol/L Four lipids: Total cholesterol = Corresponding to the 50th percentile value of age and sex No abnormal ST segment changes in exercise stress test (assessed by Bruce's protocol) Baseline physical fitness test Number of push-ups in 1 minute > = 20 reps for men / 12 reps for women Anterior flexion of the seated body > = 10 cm (5) Other access conditions Legal and Cognitive Requirements Persons with full capacity for civil conduct who hold valid identity certificates; Pre-Authorization Informed Consent Process: Read the informed consent form completely and sign it independently> designated agent reads the informed consent form and signs it independently> designated agent reads and signs the informed consent form If there is a designated agent, the designated agent is required to sign the informed consent form and the relevant documents of the agent. Study Adherence: Commitment to continuous participation in the training program (attendance >=85%) Agree to comply with the dietary management of the study side
Exclusion criteria
Exclusion criteria: 1. Participated in any interventional clinical study (including drug/device/biologics trial) within 3 months prior to enrollment; 2. History of major systemic disease (subject to clinical significance), details as follows: Circulatory diseases (e.g., coronary heart disease, hypertension over level II, severe arrhythmias) Metabolic endocrine diseases (diabetes, hyperthyroidism/hypothyroidism, etc.), urological diseases (chronic kidney disease stage 3 and above), neurological diseases (epilepsy, stroke sequelae, etc.), immune system abnormalities (primary/acquired immunodeficiency, autoimmune diseases), other systemic diseases (hematological, respiratory, psychiatric diseases, etc.); 3. Requirements for renal function limitation (serum creatinine needs to be tested by standardized testing methods) The CockcroftGault formula calculates creatinine clearance (CrCl) < 80 mL/min; CrCl = [(140-age) × body weight (kg)] / [0.814 × Scr(µmol/L)] 4. Abnormal clinical examination, any of the following clinically significant abnormalities (as judged by the investigator) at the time of enrollment: abnormal signs of physical examination, pathological changes in ECG, laboratory test values exceeding the normal range by more than 20% and persistent deviation of vital signs from the baseline value; 5. Other circumstances that are not suitable for selection: There are special circumstances that affect the integrity of the study or the safety of subjects as comprehensively assessed by the research team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin condition assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory test indicators;Anthropometric index;Exercise cardiopulmonary test;Muscle mass and quality assessment;Muscle function test;Cognitive assessment;Bone density and body composition analysis;Skin tissue biopsy;Muscle tissue biopsy;Imaging examination;Other necessary indicators of aging; | — |
Countries
China
Contacts
Public ContactGenqing Xie
The first people's hospital of Xiangtan hospital
Outcome results
None listed