Depressive Disorder
Conditions
Interventions
Experimental group :Antidepressants+rTMS stimulation
Pseudo-stimulus group :Antidepressants+iTBS pseudo stimulation
Open-label group:Antidepressants+rTMS stimulation
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Adolescent Patients with Depression: 1.Aged between 12 and 18 years, regardless of gender; all patients must be experiencing their first episode of depression; 2.Meet the diagnostic criteria for depression according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V); 3.A score of =17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); 4.Capable of completing the study-related questionnaires, assessments, and treatments; 5.Both the patient and their legal guardians fully understand the study procedures and content, agree to participate, and sign informed consent forms. Inclusion Criteria for Healthy Controls (n = 45): Healthy controls were matched for age and gender. The criteria were: 1.No history of major physical illness, head trauma, or neurological disorders; 2.A HAMD-17 score of <7; 3.No history of psychiatric disorders or family history of mental illness; 4.Both the participant and their legal guardians fully understand the study procedures and content, agree to participate, and sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1.Patients with other severe systemic diseases (including serious cardiac, renal, or hepatic conditions); 2.Diagnosed with other major psychotic disorders using the K-SADS, or with a history of suicidal ideation or suicidal/self-harming behaviors; 3.Patients who have previously received psychiatric pharmacological or physical treatments; 4.Individuals with alcohol or substance dependence; 5.Individuals with intellectual developmental disorders; 6.Individuals with metallic implants such as pacemakers or intracranial electrodes, which are contraindications for MRI and iTBS; 7.Patients who have received iTBS or MECT treatment in the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalogram;brain MRI Images;Patient Health Questionnaire-9 Score;Hamilton Depression Scale Score;Children's depression inventory score;Clinical Global Impression-severity of illness;Montgomery-Asberg deprssion sacle score;Clinical global impression-global improvement score;Repeatable Battery for the Assessment of Neuropsychological Status score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale Score;General anxiety disorder scale score;Young Mania Rating Scale Score;Positive and Negative Syndrome Score; | — |
Countries
China
Contacts
Public ContactShen Yanmei
The Second Xiangya Hospital of Central South University
Outcome results
None listed