cardiovascular outcomes
Conditions
Interventions
30%FiO2 group: FiO2 was set at 30%, maintaining SpO2=95%.
Intervention duration: From intubation to pre-extubation.
80%FiO2 group: FiO2 was set at 80% immediately after intubation.
Intervention duration: From intubation to pre-extubation.
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. Previously diagnosed diabetes or newly diagnosed diabetes upon admission (fasting blood glucose >= 7.0 mmol/L, random blood glucose >= 11.1 mmol/L, or HbA1c >= 6.5%); 3. Scheduled non-cardiac surgery (major abdominal or orthopedic surgery) requiring general anesthesia with mechanical ventilation; 4. Expected surgical duration > 2 hours and postoperative hospital stay > 48 hours.
Exclusion criteria
Exclusion criteria: 1. Preoperative SpO2 < 90% or PaO2 < 60 mmHg without oxygen supplementation; 2. Severe hepatic or renal dysfunction (e.g., Child-Pugh class C liver disease, or requiring dialysis); 3. Planned one-lung ventilation during surgery; 4. History of chemotherapy within the past 3 months; 5. History of general anesthesia surgery within the past 30 days; 6. Perioperative need to continue medications known to cause significant myocardial injury; 7. Participant refusal or inability to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovascular outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute kidney injury;Postoperative delirium; | — |
Countries
China
Contacts
Public ContactLu Yang
Shanghai Sixth People's Hospital
Outcome results
None listed