Disc degeneration diseases of the the lumbar spine
Conditions
Interventions
Group A:(Cocktail group) Group: Ropivacaine 200mg+Adrenaline 0.2mg+Dexamethasone 10mg+NS47ml
Group B:Preventive analgesia group: intravenous administration of 2mg oxaliplatin for preventive analgesia during anesthesia induction
Group C:Cocktail + preventive analgesia combination group: 2mg oxelidine was given intravenously for preventive analgesia + ropivacaine 200mg+ epinephrine 0.2
Sponsors
The First Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Age: 40 ~ 70 years old; 2 Confirmed lumbar disc herniation, lumbar spondylolisthesis or lumbar spinal stenosis; 3 1-2 stage PLIF surgery was performed; ?Preoperative American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is grade I to III.
Exclusion criteria
Exclusion criteria: 1 Patients with tuberculosis, tumor, infection, fracture, metabolic bone disease and other spinal diseases; 2 Previous history of thoracolumbar posterior surgery or trauma; 3 Patients with drug allergies used in this study; 4 Patients with heart, lung and other important organ failure or serious coagulation dysfunction; 5 Abnormal liver and kidney function (ALT, AST> 1.5 times normal value, blood BUN>-8.3 mmoll, blood Scr>115 umol/L); 6 Patients with diabetes and poorly controlled blood sugar levels who are judged by researchers to be at risk of infection; 7 There is an active infection in the body (systemic or local infection lesions); 8 Women during family planning, lactation and pregnancy throughout the clinical study period; 9 Participants who have participated in other clinical trials within 3 months or who are not suitable to participate in this clinical trial for other reasons; 10 Opioid addicts; xi. Language impairment and inability to complete the Visual analogue scale (VAS) of pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative remedial analgesia;Total opioid use before and after surgery;Postoperative dosage of remedial morphine hydrochloride; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale pain score;Postoperative recovery quality;Inflammatory index;Accelerated rehabilitation index;Complication rate; | — |
Countries
China
Contacts
Public ContactChen Changjun
The First Affiliated Hospital of Shandong First Medical University
Outcome results
None listed