Depressive Disorder
Conditions
Interventions
active tACS:The active tACS protocol lasted for 40 min of continuous sine-wave stimulation with the frequency of 10Hz and an amplitude ranging from 1.5mA to 2.0mA, adjusted according to the tolerabili
sham tACS:we use fade-in, short-stimulation, fade-out (FSF) stimulation pattern, with 30s-long fade-in/out periods. The same parameters as in the active group are used at the beginning and the end of
Sponsors
Ruijin Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. Clinical diagnosis of depressive disorder according to criteria of ICD-10; b. Age ranges between 18 and 65 years; c. HDRS-17 score equals to or above 8; d. No medical history/Under stable antidepressant treatment in one month; e. Ability and willingness to provide written informed consent; f. Good compliance, able to cooperate with follow-up visits.
Exclusion criteria
Exclusion criteria: a. Combination of other psychotic disorders and neurological diseases; b. Severe personality disorders; c. History of organic brain disease or previous seizures; d. History of invasive brain surgeries, including deep brain stimulation and non-invasive neurostimulation treatments, including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial alternating current stimulation (tACS), etc. e. Any circumstances (family support, medical, psychological, social or geographical factors) that may endanger the patient's safety or prevent the patient from successfully participating in the study at present or in the future;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences of Hamilton Depression Scale score reduction rates in two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences of treatment efficacy rates in two group ; | — |
Countries
China
Contacts
Public ContactBomin Sun
Ruijin Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed