Type 2 diabetes mellitus with subclinical hypothyroidism,diabetic cardiomyopathy
Conditions
Interventions
T2DM combined with SCH and thyroid hormone therapy intervention group:L-Thyroxine
Control group with T2DM and normal thyroid function:None
T2DM combined with SCH blank control group:None
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.T2DM patients WHO meet WHO diagnostic criteria for diabetes and have normal thyroid function or subclinical hypothyroidism; 2.Age greater than or equal to 18 years old; 3.Voluntarily sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.These include hypertensive heart disease, coronary atherosclerotic heart disease, valvular heart disease, congenital heart disease, viral cardiomyopathy or familial cardiomyopathy; 2.Combined thyroid disease (hyperthyroidism, clinical hypothyroidism, subacute thyroiditis, etc.), taking drugs that may affect thyroid function (such as thyroid hormones, iodinated preparations, glucocorticoids, etc.), history of thyroid surgery or external irradiation; 3.Patients with malignant tumors receiving radiotherapy and chemotherapy; 4.Patients with severe liver and kidney function impairment, rheumatic immune system diseases, blood system diseases and malignant tumors have lesions in the hypothalamus, pituitary gland and sella region; 5.Type 1 diabetes mellitus, specific type diabetes mellitus, acute complications of diabetes mellitus; 6.Sepsis and other acute infection, trauma, surgical period; 7.Pregnant and lactating women; 8.Bipolar disorder, schizophrenia and other severe psychiatric patients and patients with cognitive dysfunction; 9.Allergic to levothyroxine sodium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of diabetic cardiomyopathy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cardiac structure and function of subjects relative to baseline; | — |
Countries
China
Contacts
Public ContactYing Xue
Tongji Hospital of Tongji University
Outcome results
None listed