dry eye syndrome in renal transplant recipients
Conditions
Interventions
normal control group:None
Post-renal transplantation group:None
Sponsors
Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Normal control group: 1. Age of 18-70 years old; 2. signed the informed consent, voluntarily accepted and cooperated with the treatment. Post-renal transplantation group: 1. Age of 18-70 years old; 2. >6 months after renal transplantation 3. signed the informed consent, voluntarily accepted and cooperated with the treatment.
Exclusion criteria
Exclusion criteria: 1.History of ocular diseases: poor imaging quality of macular OCTA due to corneal opacity, advanced cataract or vitreous hemorrhage; Patients after vitrectomy, visual omental laser photocoagulation and anti-VEGF drug application 2.Use eye drops in the past week (e.g., antibiotic eye drops, tear substitutes, etc.) 3.OCTA image quality < 20db 4. history of neurodegenerative diseases 5. Check for lack of cooperation 6. patients with graft failure and re-dialysis 7. multiple kidney transplantation and multiple organ transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular Surface Disease Index;Tear river height;Non-invasive break-up time;Classification of meibomian gland deletion;Schirmer test;Corner and conjunctival staining score;retinal vessels area density;Fractal dimension of retinal vessels;Area of foveal avascular zone ;Perimeter of foveal avascular zone;Acircularity index of foveal avascular zone;Glomerular filtration rate;Urinary protein;Immunosuppressant Concentrations; | — |
Secondary
| Measure | Time frame |
|---|---|
| Red eye analysis;Density and morphology of conjunctival goblet cells; | — |
Countries
China
Contacts
Public ContactZhihong Deng;Yingzi Ming
Third Xiangya Hospital of Central South University
Outcome results
None listed