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Pharmacokinetics of bupivacaine liposomes in pericapsular nerve group block and lateral femoral cutaneous nerve block

Pharmacokinetics of bupivacaine liposomes in pericapsular nerve group block and lateral femoral cutaneous nerve block

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103535
Enrollment
Unknown
Registered
2025-05-30
Start date
2024-07-21
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total hip replacement due to various hip diseases

Interventions

Group I:Administer PENG block (20ml) and lateral femoral cutaneous nerve block (5ml) using liposomal bupivacaine at a concentration of 25ml:133mg
Group III:Administer PENG block (20ml) and lateral femoral cutaneous nerve block (5ml) using a mixture of 25ml (containing 133mg liposomal bupivacaine and 50mg
Group II:Administer PENG block (20ml) and lateral femoral cutaneous nerve block (5ml) using bupivacaine hydrochloride at a concentration of 25ml:50mg

Sponsors

The First Affiliated Hospital of Guangxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing unilateral THA; 2. Age> = 18 years old, gender is not limited; 3. American York Heart Association (NYHA) cardiac function grade ?~II; 4. Body mass index (BMI) is 18~30 kg/m^2; 5. No history of allergy to local anesthetic drugs.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing unilateral THA; 2. Age> = 18 years old, gender is not limited; 3. American York Heart Association (NYHA) cardiac function classification ?~II. 1. Infection at the injection site; 2. Patients have severe arrhythmia or circulatory system disease, liver and kidney dysfunction, respiratory system and coagulation system dysfunction; 3. Recent continuous use of analgesics; 4. History of local anesthetic allergy; 5. Patients who do not accept or cooperate with the block by themselves or their authorized persons; 6. Hemoglobin content: Hb<110g/L for women and 120g/L for men<;; 4. Body mass index (BMI) is 18~30 kg/m^2; 5. No history of allergy to local anesthetic drugs.

Design outcomes

Primary

MeasureTime frame
Blood concentration;

Countries

China

Contacts

Public ContactLiPei Shu

The First Affiliated Hospital of Guangxi Medical University

kyb0697@163.com+86 771 535 6250

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026