Postoperative delirium (POD)
Conditions
Interventions
Dexmedetomidine group:Received a loading dose of dexmedetomidine 0.6 µg/kg 10 minutes before induction of anesthesia, followed by a continuous infusion (0.3 µg/kg/h) until 1 hour before the end of sur
Saline solution group:Received a loading dose of saline solution 0.36 ml/kg 10 minutes before induction of anesthesia, followed by continuous infusion (0.03 ml/kg/h) until 1 hour before the end of the
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who undergo elective non-cardiac and non-neurosurgical procedures under general anesthesia; 2. Frailty was assessed by the Fried frailty phenotype 1 day before surgery; 3. Age>=60 years; 4. Those who can conduct on-site follow-up interviews, can understand and sign the informed consent form and are willing to complete neuropsychological testing; 5. American Society of Anesthesiologists (ASA) Class I-III.
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate in the study; 2. Dementia, major depressive disorder, or other severe mental or neurological disorders prior to the study; 3. Limb amputation, paraplegia; 4. There are related diseases affecting the muscles of the lower limbs (such as polio, polio, myasthenia gravis, polymyositis, etc.); 5. Heart failure, pulmonary hypertension, respiratory failure, liver and kidney dysfunction; 6. Known preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia ( 6 years) MMSE 10 points).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps thickness;Albumin;Hemoglobin;Quality of recovery;Length of stay;Postoperative complication;Postoperative pain score; | — |
Countries
China
Contacts
Public ContactYueying Zhang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed