Ejection fraction preserving heart failure
Conditions
Interventions
Colchicine treatment group:NA
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Meet one of the following criteria: Meet the clinical diagnostic criteria for HFpEF in the ESC guidelines for the diagnosis and treatment management of acute and chronic heart failure; Gold standard: Undergo left heart catheterization and be diagnosed with HFpEF. The diagnostic criteria are LVED >=15 mmHg, or when 10 mmHg =19 mmHg. The straight leg raising test can effectively differentiate occult HFpEF, with a specificity of 100% in diagnosing occult HFpEF and without interference from the use of diuretics by the patient. Elevation of one or more inflammatory factors (IL-6, IL-8, TNF-a).
Exclusion criteria
Exclusion criteria: 1. Echocardiography indicates an ejection fraction of less than 50% (currently or previously); 2. Patients under the age of 18 years; 3. Patients with myocardial ischemia due to coronary artery stenosis requiring further interventional treatment; 4. Patients with abnormal liver or kidney function, eGFR = 60%, AST or ALT > 3 times the normal value; 5. Patients with respiratory diseases, congenital heart disease, significant valvular heart disease (more than mild stenosis, more than moderate regurgitation), pulmonary hypertension, constrictive pericarditis, primary cardiomyopathy, or cardiac transplantation; patients with severe infections, malignant tumors, or an expected survival of less than one month; 6. Patients with other indications for colchicine treatment or a history of intolerance to colchicine; 7. Other reasons or deemed unsuitable for this trial by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 1ß;Interleukin 2;Interleukin 5;Interleukin 6;Interleukin 8;Interleukin 10;Interleukin 4;Tumor necrosis factor a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton anxiety scale (HAMA);Hamilton depression scale (HAMD);Kansas City Cardiomyopathy Patients Quality of Life Scale (KCCQ);Liver function;renal function;Blood routine examination; | — |
Countries
China
Contacts
Public ContactLiu Chao
The First Hospital of Hebei Medical University
Outcome results
None listed