Diabetic foot ulcers
Conditions
Interventions
Control group:Standard treatment for diabetic foot
Topical estrogen group:Topical estrogen+Standard treatment for diabetic foot
FGF group:Topical FGF+Standard treatment for diabetic foot
Topical estrogen+topical FGF group:Topical estrogen+topical FGF+Standard treatment for diabetic foot
Sponsors
Wenzhou Medical University First Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Type 1 or type 2 diabetes that meets the 1999 WHO diagnostic criteria for diabetes (2) Wagner grade 1-4 diabetic foot ulcers (3) Age >=18 years old but =0.3 but =1 cm2 and <= 60 cm2 (6) The subjects understood the content of this study and agreed to participate (7) Female
Exclusion criteria
Exclusion criteria: (1)Hemoglobin =180mmHg or diastolic blood pressure>=110mmHg (3) Confirmed or suspected breast cancer, or a previous history of breast cancer (4) Newly diagnosed or suspected estrogen-dependent organisms (such as endometrial cancer, endometrial hyperplasia) (5) Active or previously diagnosed venous thromboembolism (such as deep vein thrombosis, pulmonary embolism) (6) Active or recently suffering from arterial thromboembolic diseases (such as cerebral infarction). Myocardial infarction (7) Poor liver function or liver diseases (8) Patients who have suffered semi-blindness, total blindness or diplopia due to ocular vascular diseases (9) There are concurrent malignant tumors that may affect life expectancy. (10) Creatinine > 200µmol/L or creatinine clearance rate < 30 ml/min (11) Confirmed or suspected pregnancy (12) Undiagnosed abnormal bleeding of the reproductive tract
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The complete skin healing rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of patients with >75% granulation tissue formation at 2, 4, and 8 weeks;Percentage of patients with complete skin healing at week 20;Time required for granulation tissue to form >75%;The time required to achieve complete skin healing;Rates of major and minor amputations and recurrence; | — |
Countries
China
Contacts
Public ContactHong Jing
Wenzhou Medical University First Affiliated Hospital
Outcome results
None listed