Attention Deficit Hyperactivity Disorder
Conditions
Interventions
Gold Standard:After 12 weeks of pharmacological treatment using methylphenidate, the ADHD rating scale will be applied, and a reduction rate of the total score =25% will be treated as "effective."
Index test:polygenic risk score, and brain features extracted from multimodal imaging data
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 15 Years
Inclusion criteria
Inclusion criteria: Children with ADHD: Patients were treated in the outpatient Department of Child Health Care of Shenzhen Children's Hospital. According to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-?), Combined with clinical interviews and according to the K-SADS-PL (Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Aged Children Present and Lifetime Version, School-age Children's Affective Disorders and Schizophrenia Questionnaire (current and Lifetime version) diagnostic tool semi-structured interview, children diagnosed with ADHD, excluding childhood schizophrenia, mood disorders, Tourette syndrome, or other mental disorders that met DSM-? axis I diagnosis. Due to the high prevalence of ADHD with opprosive defiant disorder (ODD) and conduct disorder (CD), these two types of comorbidities were not excluded in this study. Normal control group: Healthy children from ordinary primary and secondary schools in Shenzhen who received interviews with parents and children using K-SADS-PL to exclude the possibility of ADHD and other current or previous mental disorders. The inclusion criteria for all subjects included: 1) age 6-15 years old, right-handed; 2) no history of severe traumatic brain injury leading to coma; 3) no nervous system disease or other serious physical disease; 4) The total score of Wechsler Intelligence Scale for Chinese children =80 points; 5) uncorrected visual acuity or corrected visual acuity =1.0, without color blindness or color asthenia; 6) There are no conditions such as the presence of metal implants (including non-removable dentures) or claustrophobia that would be inappropriate for MRI; 7) no neurological abnormalities (e.g., ventricular enlargement) on structural MRI by imaging experts; 8) never used ADHD-related medications, including central stimulants or non-central stimulants.
Exclusion criteria
Exclusion criteria: Children with ADHD: Childhood schizophrenia, mood disorders, Tourette syndrome, or other mental disorders that met DSM-? axis ? diagnosis were excluded; Normal control group: The possibility of ADHD and other current or previous mental disorders diagnosis was excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactZhaomin Wu
Shenzhen Children's Hospital
Outcome results
None listed