neuromuscular blockade
Conditions
Interventions
research group:Administer 2 mg/kg of sugammadex sodium intravenously at the end of surgery
control group:Administer 0.04 mg/kg neostigmine and 0.02 mg/kg atropine intravenously after surgery
Sponsors
Kunshan Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age 60 or older; (2) Patients scheduled for surgery under general anesthesia; (3) Modified Frailty Index MFI 3 or higher; (4) Planned extubation after surgery; (5) Informed consent, voluntary participation in the trial, and signing the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with severe liver or kidney dysfunction; (2) those currently taking medications such as phenytoin that affect the efficacy of rocuronium; (3) individuals with neuromuscular diseases or peripheral neuropathy; (4) patients allergic or resistant to aminosteroids; (5) pregnant or breastfeeding women; (6) participants who have taken part in other drug clinical trials within the last three months; (7) patients deemed unsuitable for this trial by the investigator or who refuse to participate themselves.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| residual muscle relaxation rate;Incidence of hypoxemia;The levels of serum CRP and PCT;Incidence of complications; | — |
Countries
China
Contacts
Public ContactQiao Shigang
Kunshan Traditional Chinese Medicine Hospital
Outcome results
None listed