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A multicenter randomized controlled clinical study of pericardial fenestration for the prevention of atrial fibrillation after coronary artery bypass grafting

A multicenter randomized controlled clinical study of pericardial fenestration for the prevention of atrial fibrillation after coronary artery bypass grafting

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103483
Enrollment
Unknown
Registered
2025-05-29
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

Posterior left pericardiotomy group:Posterior left pericardiotomy is performed by qualified and experienced doctors from each center at the same time as coronary artery bypass surgery. The specific me
control group:No posterior left pericardiotomy was performed, only mediastinal drainage tube was placed.

Sponsors

General Hospital of Northern Theater command
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Over 18 years old 2. No previous history of atrial fibrillation 3.LVEF>40% 4. No history of myocardial infarction 5. Coronary artery bypass surgery (on-pump, off-pump) due to coronary atherosclerotic heart disease 6. Agree to accept the protocol, sign the informed consent form, and be able to cooperate with the collection, storage and follow-up process of medical history data

Exclusion criteria

Exclusion criteria: 1. History of preoperative atrial arrhythmia 2. Cardiac surgery other than coronary artery bypass surgery at the same time 3. Emergency surgery 4. Minimally invasive surgery 5. Reoperation 6. Left pleural disease 7. Thoracic deformity 8. Those who participated in other clinical trials within 3 months before enrollment and have not been discharged 9. Cardiac surgery accompanied by surgery on other body parts; 10. Patients with liver and kidney function impairment (test results exceed 3 times of the upper limit of normal value) and have contraindications to surgery; 11. Those who have other diseases and need radiotherapy, chemotherapy, or long-term hormone therapy; 12. Patients with hyperthyroidism 13. Other reasons are not suitable for joining the study

Design outcomes

Primary

MeasureTime frame
Incidence of new atrial fibrillation after surgery;Percentage of atrial premature beats in total heartbeats during the monitoring period.;Percentage of atrial paired premature beats during the monitoring period as a percentage of total heartbeats;Percentage of atrial tachycardia episodes during monitoring period to total heartbeats;

Secondary

MeasureTime frame
Duration of atrial fibrillation;Atrial fibrillation burden;HRV metrics;Whether antiarrhythmic drugs are used for POAF;Whether to perform systemic anticoagulation therapy for POAF.;Whether electrical cardioversion is used for the treatment of POAF.;Days of ICU length of stay;Days of Postoperative hospital stay ;Hospitalization expenses;Readmission;

Countries

China

Contacts

Public ContactHuishan Wang

General Hospital of Northern Theater command

huishanwang@hotmail.com+86 24 2889 7381

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026