Infantile autism
Conditions
Interventions
Autism + Saline (Group A):Group A was given equal dose of normal saline
Autism + dexmedetomidine (Group A+D):Patients in group A+D were given intravenous dexmedetomidine at 0.20-0.40 µg/(kg·h) after anesthesia
Sponsors
Stomatology Hospital Affiliated to Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 14 Years
Inclusion criteria
Inclusion criteria: Children with autism: 1) The biological age is 2-12 years old; 2) Meet the diagnostic criteria for autism spectrum disorder in the Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 3) Children diagnosed with ASD by the ADORS2 gold Standard for autism assessment; 4) General anesthesia caries were treated in our hospital and no contraindications were detected by anesthesiologists in our department; 5) Subject's guardian signs the informed consent. Normal children: 1) No child mental illness or other heart, lung, kidney and other physical diseases 2) General anesthesia caries were treated in our hospital and no contraindications were detected by anesthesiologists in our department 3) Subject's guardian signs the informed consent
Exclusion criteria
Exclusion criteria: Children with autism: 1) accompanied by other serious heart, lung, kidney and other physical diseases; 2) Received general anesthesia within three months; 3) Allergic to Dex; 4) Other sedatives have been used within 48 hours; 5) bradycardia; 6) Respiratory infection; 7) Any person who has difficulty in understanding the test plan and cannot follow the test plan Normal children: 1) accompanied by other serious heart, lung, kidney and other physical diseases; 2) Received general anesthesia within three months; 3) Allergic to Dex; 4) Other sedatives have been used within 48 hours; 5) bradycardia; 6) Respiratory infection; 7) Any person who has difficulty in understanding the test plan and cannot follow the test plan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism Treatment Assessment Scale (ATEC);Behavioral Checklist for Autistic Children (ABC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery from general anesthesia in children (PAED score);Pain scores for children during recovery;Expiration time;Awakening time;Pre-anesthetic vital signs;Tracheal catheter was inserted into immediate vital signs;Tracheal catheter removal is vital sign;Wake up with vital signs;Regular medication;Postoperative respiratory depression;nausea and vomiting;Bed fall event; | — |
Countries
China
Contacts
Public ContactXiaoping Zhang
Stomatology Hospital Affiliated to Wenzhou Medical University
Outcome results
None listed