Stroke
Conditions
Interventions
BCI group:BCI training add-on to standard therapy
BCI+rTMS group:Sequential rTMS followed by BCI training add-on to standard therapy
Conventional rehabilitation group:Conventional rehabilitation therapy alone
Sponsors
Longgang District People's Hospital, Shenzhen, Guangdong, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18 to 80 years old. (2) Diagnosis: Stroke confirmed by the diagnostic criteria established at the 4th National Cerebrovascular Disease Academic Conference (1995, China). (3) Disease Status: First-onset unilateral hemiplegia, with a disease course of 2 weeks to 6 months post-stroke. (4) Hand Dysfunction: Moderate-to-severe hand dysfunction (Brunnstrom stage <=4, MAS score <=3). (5) Cognitive Function: No severe cognitive impairment; ability to follow instructions and perform hand movements (e.g., grasping). (6) Medical History: - No severe hepatic/renal dysfunction, traumatic brain injury, drug/alcohol dependence, or other conditions that may affect brain structure/function. - No comorbid psychiatric disorders. (7) Physical Ability: Ability to sit independently or with support for =1 hour. (8) Consent: Voluntarily participation with signed informed consent.
Exclusion criteria
Exclusion criteria: (1) History of two or more strokes (recurrent stroke). (2) Pre-existing limb dysfunction due to other causes (e.g., trauma, neuropathy) prior to the current stroke. (3) Severe cardiac, pulmonary, or renal complications. (4) Other neurological disorders, inability to cooperate with training, or poor treatment compliance. (5) Cognitive impairment (MMSE <21), visual or hearing deficits. (6) Sensory aphasia or mixed aphasia. (7) Unstable fractures, infections, or active bleeding in the affected hand.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment (FMA) - Hand/Wrist Subscale;Action Research Arm Test, ARAT;Wolf Motor Function Test, WMFT; | — |
Secondary
| Measure | Time frame |
|---|---|
| ADL;DTI; | — |
Countries
China
Contacts
Public ContactWang Benguo
Longgang District People's Hospital, Shenzhen, Guangdong, China
Outcome results
None listed