Anti-LGI1 Encephalitis
Conditions
Interventions
Patients with anti-LGI1 encephalitis:Nil
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Diagnosis of autoimmune encephalitis meeting the 2016 diagnostic criteria published in The Lancet Neurology and the 2022 Chinese Expert Consensus on Diagnosis and Treatment of Autoimmune Encephalitis. (2) Written informed consent obtained from the patient or their legal guardian after a full explanation of the study objectives, procedures, potential risks, and benefits.
Exclusion criteria
Exclusion criteria: (1) Presence of metal implants (e.g., cochlear implants, pacemakers) that may interfere with MRI or MEG examinations. (2) History of other confirmed neurological disorders, such as traumatic brain injury, stroke, epilepsy, or neurodegenerative diseases, or major psychiatric disorders (e.g., schizophrenia, bipolar disorder). (3) Clinically significant systemic diseases (e.g., uncontrolled diabetes, malignancy, severe hepatic or renal dysfunction). (4) Inability to cooperate with EEG, MEG, or MRI data acquisition or neuropsychological assessments. (5) Anticipated inability to complete study follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain structural parameters;Brain structural parameters;Cognitive function, executive function, memory and learning, language and fluency assessment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid test indicators;Serological test indicators;Treatment;Clinical manifestation; | — |
Countries
China
Contacts
Public ContactXiaoshan Wang, Ailiang Miao
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing
Outcome results
None listed