carbapenem-resistant gram-negative bacteria (CRO) infection
Conditions
Interventions
treatment group:Anti-infective treatment with polymyxin E sodium mesylate
control subjects:Treatment with antibiotics other than polymyxin E sodium mesylate such as cefoperazone/sulbactam, piperacillin/tazobactam, imipenem/cilastatin, merope
Sponsors
Hangzhou Linping Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. The pathogen was confirmed by microbiology to be CRO, and the antimicrobial susceptibility test was sensitive to CMS (the specimen was sputum culture, alveolar lavage fluid culture, blood culture, and urine culture); 3. The treatment time of CMS in the treatment group was = 72 hours.
Exclusion criteria
Exclusion criteria: 1. Age< 18 years old; 2. CRO colonization or contamination; 3. The treatment time of CMS in the treatment group was < 72 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WBC, NEUT%, CRP, PCT, IL-6;The infection type, microbial species, and infection indicators;Bacterial clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The days of ventilator use and ICU stay ;Safety evaluation;Vital signs: body temperature, heart rate, respiratory rate, blood pressure, oxygen saturation; | — |
Countries
China
Contacts
Public ContactLyu Cong
Hangzhou Linping Hospital of Traditional Chinese Medicine
Outcome results
None listed