Uterine fibroids
Conditions
Interventions
Esketamine Group (E):Esketamine 0.3 mg/kg intravenous bolus was administered, followed by continuous intravenous injection of esketamine at a dose of 1.2 mg/kg/hour with a micropump until the skin was
This is followed by an intravenous self-controlled analgesic pump equipped with esketamine
Saline group (S group):Intravenous bolus injection of the same volume of normal saline as in the intervention group, followed by continuous intravenous pumping of normal saline at the same rate as the
This is followed by an ordinary intravenous self-controlled analgesic pump
Sponsors
Xinxiang Central Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 35-65 years old; 2. Body weight refers to 18-28kg/m^2; 3. ASAI. or Class II; 4. Patients diagnosed with uterine fibroids who underwent elective single-port laparoscopic total hysterectomy.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in clinical observation; 2. History of psychiatric illness; 3. Patients with a history of cerebrovascular accident, increased intracranial pressure, intracranial space-occupying lesions, glaucoma, hyperthyroidism and other contraindications to esketamine; 4. Those with a history of epilepsy or manic seizures; 5. Those with a history of malignant tumors; 6. History of gynecological surgery; 7. Those who cannot use WeChat to complete the questionnaire independently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HADS depression score 6 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative, 48h, 72h, 1 month, 3 months HADS score and 6 months HADS anxiety score;Resting state and active NRS pain scores at 24, 48, and 72 h postoperatively;Intraoperative use of anesthetic and analgesic drugs;On the third day after surgery, the patient's satisfaction score with the analgesic effect in the hospital was evaluated (using VAS score, 0= very dissatisfied, 1-3= dissatisfied, 4-6= neutral, 7-9= satisfied, 10= very satisfied).;Incidence of postoperative adverse reactions to opioids, such as nausea, vomiting, and pruritus;Postoperative gastrointestinal function recovery time: first anal exhaust time (h), defecation time (h); | — |
Countries
China
Contacts
Public ContactShao Kun
Xinxiang Central Hospital
Outcome results
None listed