Type A Aortic Dissection
Conditions
Interventions
Test Group:Anesthesia and perioperative management were identical to the control group. In addition to conventional blood management strategies, patients received preoperative autologous platelet aphe
Control Group:General anesthesia with endotracheal intubation and cardiopulmonary bypass was used. Anesthesia was maintained with propofol, sevoflurane, sufentanil, and rocuronium. Standard monitoring
integrated oxygenators were used without emphasis on ultrafiltration.
At the end of surgery, heparin was reversed using a decision-support-guided protamine dosing strategy. Coagulation was assessed us
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Undergoing open surgery for type A aortic dissection (TAAD); 2. Body weight between 60–100 kg, hemoglobin (Hb) > 120 g/L, and platelet count (PLT) >= 120 × 10?/L; 3. Able to understand the purpose of the study, voluntarily participate, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Requiring mechanical ventilation before surgery; 2. Age over 70 years or under 18 years; 3. Discontinuation of anticoagulant and/or antiplatelet therapy less than 7 days before surgery; 4. Occurrence of cardiogenic shock, cardiac arrest, severe hypotension (requiring two or more vasoactive agents), or use of mechanical circulatory support within 24 hours before surgery; 5. Concomitant renal failure requiring renal replacement therapy; 6. Severe coagulopathy or significant bleeding tendency; 7. Known history of heparin-induced thrombocytopenia (HIT); 8. Diagnosed with severe psychiatric disorders or considered likely to affect study outcomes; 9. Any other condition that, in the judgment of the investigator, may affect study results or patient safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hourperioperative RBC transfusion volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative bleeding volume;24-hour postoperative chest tube drainage volume;Perioperative and inpatient blood product usage;ICU stay time and hospitalization time;Postoperative complications; | — |
Countries
China
Contacts
Public ContactSheng Wang
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed