Postoperative Nausea and Vomiting
Conditions
Interventions
Control group:4 ml of normal saline intravenous infusion is given prior to anesthesia induction
Experimental group:0.2g/4ml vitamin B6 and 2M normal saline intravenous infusion was given before anesthesia induction
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients who intend to undergo gynecological laparoscopic surgery, cholecystectomy, otolaryngology surgery, thyroidectomy, and breast surgery under general anesthesia; (2) Age 18~80 years old; (3) ASA Class I.~III; (4) Provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Known allergy to VitB6 or use of VitB6 within one week before surgery; (2) Use of long-acting antiemetics and emetic drugs within one week before surgery; (3) Long-term use of opioids or glucocorticoids; (4) Have other medical conditions that may cause nausea and/or vomiting, such as hepatitis or stomach ulcers; (5) Postoperative gastric tube treatment; (6) Pregnancy or lactation; (7) Mental retardation, mental illness or severe neurological disease; (8) Participate in other clinical studies; (9) Refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting in the early postoperative period;Incidence of nausea and vomiting in late postoperative stages;Incidence of postoperative nausea;Incidence of postoperative vomiting;The severity of the patient's nausea at 24 hours postoperatively (0 none; 1 mild; 2 medium; 3 violent);The severity of the patient's vomiting at 24 hours postoperatively (0 none; 1 mild; 2 medium; 3 violent);Frequency of vomiting (1, 2, >=3);Time to first onset of postoperative nausea and vomiting;Treatment of anti-nausea medications;Maximum pain score at rest/exercise within 24 hours postoperatively;Morphine equivalent dose used within 24 hours postoperatively;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactLe Yuan
Department of Anesthesiology, Third Xiangya Hospital, Central South University
Outcome results
None listed