patients undergoing hysteroscopy
Conditions
Interventions
Remimazolam high-dose group (0.3 mg/kg):The initial dose of alfentanil is 10 ug/kg, and the sequential dose is 1 ug/kg.
Remimazolam low-dose group (0.2 mg/kg):The initial dose of alfentanil is 10 ug/kg, and the sequential dose is 1 ug/kg.
Sponsors
The First Affiliated Hospital of Shan Tou University Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, female, BMI 18-30 kg/m^2; 2. ASA (American Society of Anesthesiologists) physical status I-II; 3. Scheduled for hysteroscopy; 4. Informed consent obtained; 6.BMI 18-24 kg/m²;
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation; 2. Known history of allergy to opioids (e.g., alfentanil) or benzodiazepines (e.g., remimazolam); 3. Long-term use of sedatives, analgesics, or antidepressants (>3 months); 4. Severe cardiovascular diseases (e.g., uncontrolled hypertension, arrhythmias, cardiac function class III-IV); 5. Psychiatric disorders or communication impairments preventing cooperation with assessments; 6. Severe hepatic or renal dysfunction (ALT/AST > 2× upper limit of normal [ULN], serum creatinine [Cr] > 1.5× ULN); 7. Patients with myasthenia gravis;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alfentanil Dosing for Effective Pain Control During Hysteroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay Sedation Score;Adverse Event Outcomes;Vital signs: MAP, HR, SpO2; | — |
Countries
China
Contacts
Public ContactWei Sun
The First Affiliated Hospital of Shan Tou University Medical College
Outcome results
None listed