postoperative delirium
Conditions
Interventions
Preoperative Training Group:VR cognitive function training
Preoperative Non-Training Group:Virtual Scene
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=65; 2. Preoperative MRI-confirmed cerebral small vessel disease; 3. Scheduled to undergo non-cardiac, non-craniotomy procedures under general anesthesia; 4. Anticipated surgical duration >2 hours; 5. ASA physical status classification: I–III; 6. No use of cognitive-enhancing medications within 3 months prior to surgery; 7. Voluntary participation with signed informed consent;
Exclusion criteria
Exclusion criteria: 1. Contraindications to cranial MRI (e.g., cardiac pacemaker, metallic implants, etc.); 2. Intolerance to VR equipment during pre-training adaptation (e.g., dizziness, nausea, vomiting, or other subjective discomfort); 3. Severe visual or auditory impairment; 4. Severe hepatic or renal dysfunction; 5. Pre-existing neuropsychiatric disorders (e.g., schizophrenia, epilepsy, Parkinson’s disease, or active delirium); 6. Inability to complete preoperative neuropsychological assessments (e.g., dementia, deaf-mutism, or communication barriers); 7. History of cerebrovascular events within 3 months (e.g., stroke or transient ischemic attack); 8. Use of sedatives, antidepressants, or history of psychoactive substance abuse/alcoholism;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function;Amplitude of Low-Frequency Fluctuation(ALFF) of brain region;Regional Homogeneity(ReHo) of brain region;Fractional Amplitude of Low-Frequency Fluctuation(fALFF) of brain region; | — |
Countries
China
Contacts
Public ContactZhengqian Li
Peking University Third Hospital
Outcome results
None listed