Scar
Conditions
Interventions
Intervention Group:The procedure involves harvesting a split-thickness skin graft (0.2-0.3 mm) from a concealed donor site under local anesthesia, followed by enzymatic digestion and mechanical proces
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
10 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 10 to 60 years (inclusive) 2. Hypopigmented scars with a minimum surface area of 1 cm² 3.Stable hypopigmentation (no progression for >=12 months) confirmed by serial clinical photography 4.History of inadequate response to fractional laser therapy (<=20% repigmentation observed 4 weeks post-treatment via VISIA® analysis)
Exclusion criteria
Exclusion criteria: 1.Suspected keloid predisposition OR History of keloid formation OR Family history of hypertrophic scarring; 2.Active severe dermatoses or autoimmune disorders including: Psoriasis, Scleroderma, Vitiligo, Systemic lupus erythematosus; 3.Uncontrolled Systemic Diseases, clinically significant or unstable systemic conditions that may interfere with safety assessments: Malignancy (within 5-year remission period), Poorly controlled diabetes (HbA1c >8%), Uncontrolled hypertension (BP >160/100 mmHg despite medication), Active pulmonary infections (CT-confirmed), Organic renal/hepatic dysfunction (eGFR 480 ms) 4.Patients and/or legal guardians with unrealistic treatment expectations (validated by Decision Regret Scale score >25)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Repigmentation Rate of Hypopigmented Scars; | — |
Secondary
| Measure | Time frame |
|---|---|
| Repigmentation Status of Hypopigmented Scars;Scar Improvement Evaluation;Patient Satisfaction; | — |
Countries
China
Contacts
Public ContactXiaoli Wu
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed