cIAI
Conditions
Interventions
Observation group:None
Sponsors
Affiliated Hospital of Jinggangshan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. ICU patients with confirmed complicated intra-abdominal infections, hospital-acquired pneumonia, or ventilator-associated pneumonia; ICU patients with Gram-negative bacterial infections (Klebsiella pneumoniae, Enterobacter cloacae, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa) that are sensitive to CAZ-AVI and have limited therapeutic options; 3. APACHE-II score >= 15 points; 4. Decided to use CAZ-AVI for infection treatment based on medical advice, and microbiological sampling was conducted before using CAZ-AVI; 5. Patients or their family members voluntarily sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Patients with mental disorders or inability to cooperate with treatment and follow-up; 2. Individuals who are allergic to any excipients in the active substance or CAZ-AVI component. Individuals allergic to cephalosporin antibiotics. Severe hypersensitivity to other types of beta lactam antibiotics (such as penicillin, monoacylpenicillin, or carbapenems) (e.g. rapid allergic reactions, severe skin reactions); 3. Patients who have participated in other interventional treatment trials; 4. Pregnant and lactating women; 5. Patients with confirmed or suspected viral, fungal, or parasitic pneumonia; 6. Patients who, as judged by the investigator, have other diseases that may affect the assessment of efficacy, such as active pulmonary tuberculosis, cystic fibrosis of the lungs, pulmonary granulomatous diseases, lung transplantation, etc. 7. Patients with an expected survival period of less than 48 hours; 8. Patients with carbapenem resistant Acinetobacter baumannii infection; 9. Patients who, in the investigator's opinion, have any other factors that make them unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In-hospital mortality rate;White blood cell count;Clinical response rate;Discharge destination;CRP;Bacterial clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay;Mechanical ventilation days;PCT;IL-6;Lymphocyte count;Adverse events;SOFA score;days of vasopressor use;Convenience assessment; | — |
Countries
China
Contacts
Public ContactHuazhang Wei
Affiliated Hospital of Jinggangshan University
Outcome results
None listed