The immunity of cancer patients decreases after chemotherapy
Conditions
Interventions
QuanShiJinKe microproteins taking group:QuanShiJinKe microproteins
Sponsors
Affiliated Hospital of Jinggangshan University
Eligibility
Sex/Gender
All
Age
10 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Select patients from the oncology department who have undergone surgery or are currently undergoing radiotherapy or chemotherapy, with an age requirement of 10 years or older and 75 years or younger; 2. Based on clinical history, symptoms, signs, and imaging data, the diagnosis is confirmed by pathology as a tumor; 3. The tumor patient has not received surgical treatment and is planned to undergo radiation therapy combined with synchronous therapy; 4. Weight loss, but less than 10%; 5. Decreased dietary intake, but greater than 60% of the target feeding amount; 6. PG-SGA (Patient Generated Subjective Global Assessment) score = 4 points; 7. Organ function is good, including sufficient bone marrow reserve function: absolute neutrophil (lobulated and banded) count (ANC) = 1.5 × 109/L, platelets = 100 X 109/L, and hemoglobin = 9g/dL. Liver: Bilirubin = 1.5 times normal E-limit (× ULN), alkaline phosphatase (AP), aspartate aminotransferase (ASll), and alanine aminotransferase (ALT) 1.5XULN. Kidney: Creatinine clearance rate (Ccr) calculated according to Cockcroft and Gault formulas is 980 mL/min. 8. Expected lifespan = 12 weeks; 9. Can understand the purpose and adverse reactions of the study, patients and their relatives have given informed consent to participate in this study and voluntarily signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Severe malnutrition (weight loss>10% or serum albumin<30 g/L or BMI<18.5 kg/m2); 2. Serious heart, lung, and brain diseases, etc; 3. Combined with severe renal insufficiency; 4. Combined infection related fever; 5. The existence of uncontrollable diabetes or other metabolic diseases; 6. There is intestinal obstruction that prevents diet and enteral nutrition; 7. Patients who are known to be allergic or intolerant to any component of parenteral or enteral nutrition for research purposes; 8. Alcohol or drug addiction: pregnancy or breastfeeding; Or women of childbearing age refuse contraception; 9. Patients with severe brain metastases from tumors; 10. Obstructing the signing and understanding of informed consent by individuals; 11. Patients who, for any other reason, cannot complete this study as determined by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine;Blood biochemistry;Immunity;Patient weight changes,;Non fat components,;Skeletal muscle changes,; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body improvement after treatment; | — |
Countries
China
Contacts
Public ContactShengping Long
Affiliated Hospital of Jinggangshan University
Outcome results
None listed