disorder of consciousness
Conditions
Interventions
DoC patient group A:tFUS for thalamic targets and other conventional treatments were performed first, and after washout for more than a month, tFUS for cerebellar targets and other conventional treatm
DoC patient group B:tFUS for cerebellar targets and other conventional treatments were performed first, and after washout for more than a month, tFUS for thalamic targets and other conventional treatm
Healthy subjects: thalamic tFUS group:Healthy subjects performed thalamic tFUS and cerebellar tFUS in random order, each stimulation was performed once, and the interval between the two different stim
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with disorders of consciousness: 1. Age >=18 years old; 2. Disturbance of consciousness caused by traumatic brain injury; 3. the course of disease >=2 weeks; 4. Vegetative State/unresponsive wakefulness syndrome (Vegetative State, CRS-R) according to clinical diagnostic criteria and Coma Recovery Scale-Revised (CRS-R) VS/ Unresponsive Wakefulness Syndrome (UWS) or Minimal Conscious State (MCS); 5. stable vital signs and no progressive neurological symptoms; 6. if the use of consciousness improving drugs for at least 2 weeks, no dose adjustment during the enrollment period; 7. Voluntary participation and signed informed consent. Healthy subjects: 1. Age >=18 years old; 2. no known disease or prescription medication, normal neurological examination; 3. Subjects with alcohol abuse, insufficient sleep, nervous system disease, cardiovascular disease, epilepsy, cochlear implant and other contraindications to transcranial magnetic stimulation were excluded; 4. voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe vascular sclerosis; 2. Intracranial hypertension, severe hydrocephalus, intracranial infection; 3. Metallic or electronic device implants (e.g., pacemakers, cochlear implants, deep brain stimulators, spinal cord stimulation, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt, etc.); 4. Unstable heart disease and high blood pressure; 5. other serious diseases that may affect the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Full Outline of UnResponsiveness;Persistent Vegetative State Scale;electroencephalogram results;Computed Tomography results;Functional Near-Infrared Spectroscopy results;Functional Magnetic Resonance Imaging results; | — |
Countries
China
Contacts
Public ContactXiquan Hu
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed