Hypotension after induction of anesthesia
Conditions
Interventions
etomidate group:Etomidate 0.25 mg/kg/min
Remimazolam group:Remimazolam 0.2mg/kg/min
Ciprofol group:Ciprofol 0.3 mg/kg/min
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 65 and 80; (2) Elective non-cardiovascular surgery under general anesthesia with tracheal intubation; (3)ASA grades I to III; (4) No history of cognitive impairment or able to provide informed consent.
Exclusion criteria
Exclusion criteria: (1) BMI of >= 30 kg/m^2; (2) history of cerebral or thoracic/abdominal aortic aneurysm; (3) allergy to any drugs administered in the study; (4) moderate to severe liver function impairment, namely, ChildePugh class B or C; (5) currently undergoing maintenance dialysis; (6) congestive heart failure; (7) untreated or unstable ischaemic heart conditions; (8) history of severe aortic or mitral valve disease; (9) multiple premature ventricular contractions, multiple atrial premature contractions, or atrial fibrillation; (10) use of antidepressant drugs or antipsychotics; (11) presence or anticipation of airway management difficulties;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of General Anaesthesia-Induced Hypotension, GAIH; | — |
Secondary
| Measure | Time frame |
|---|---|
| minimum MAP after induction;maximum MAP after tracheal intubation;minimum HR after loss of consciousness;number of administrations of vasopressor;time from initiation of anaesthetic administration until loss of consciousness; induction dose of anaesthetic;Incidence of injection pain;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactHuang Shaoqiang
Obstetrics and Gynecology Hospital of Fudan University; The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed