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A Randomized Controlled Trial of Liposomal Bupivacaine TAP Block for Postoperative Analgesia Following Cesarean Section

A Randomized Controlled Trial of Liposomal Bupivacaine TAP Block for Postoperative Analgesia Following Cesarean Section

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103390
Enrollment
Unknown
Registered
2025-05-28
Start date
2025-03-19
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section

Interventions

PCIA group: Intravenous patient-controlled analgesia combined with intrathecal morphine (nalbuphine 2mg/kg) + ITM 2mg:The patient received a patient-controlled intravenous analgesia device with a conc
Group LB: Liposomal bupivacaine transversus abdominis plane block combined with intrathecal morphine (LB 266 mg TAP + ITM 2 mg):Abdominal transverse fascia plane block was performed using 266mg of bup
ITM group: Intrathecal morphine ITM 2mg:Only 2mg of morphine was administered intrathecally

Sponsors

Meishan maternal and child care service center
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1 The patient's age is 20~35 years old; 2 American Association of Anesthesiologists (ASA) physical condition grade I-II 3 With a BMI of 20 ~ 35 kg/m^2, 4 full-term parturients with cesarean section under spinal anesthesia were selected.

Exclusion criteria

Exclusion criteria: 1 Previous cesarean section >= 3 times, 2 BMI>40 kg/ m^2, 3 Serious heart, lung, liver, kidney and other important organ diseases, contraindications of spinal anesthesia, mental illness or cognitive impairment, 4 allergic or contraindications to drugs used in this study, and refusal to participate in the study.

Design outcomes

Primary

MeasureTime frame
Total opioid consumption (MME) of morphine mg equivalent at 72h after operation.;

Secondary

MeasureTime frame
The NRS scores of patients at rest and during exercise at 6, 12, 24, 48 and 72 hours after operation.;Time of first anal exhaust after operation;Postoperative hospitalization time;Ramsay sedation score at 24, 48 and 72 hours after operation.;Incidence of postoperative adverse reactions;Satisfaction rate of analgesia;

Countries

China

Contacts

Public ContactLiu Li

Meishan maternal and child care service center

liuli820124@163.com+86 189 9036 0695

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026