Coronary heart disease
Conditions
Interventions
Remote ischemic preconditioning group:One day before surgery, a blood pressure cuff was wrapped around the upper arm and inflated to 200 mm Hg. This was maintained for 5 minutes, followed by deflation
Repeated remote ischemic preconditioning group:Remote ischemic preconditioning (RIPC) was performed on the day before surgery and the day of surgery, using the same method as the traditional RIPC grou
Control group:No intervention, patients are directly taken to the operating room for treatment.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 .Age >= 18 years; 2. Selected for surgical procedures under cardiopulmonary bypass (CPB) 3.Preoperative levels of cTnI and CK-MB are normal. 4. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe neurological dysfunction or concurrent tumors; 2. Oral administration of sulfonylurea hypoglycemic drugs within the past three months; 3. Active rheumatic diseases, recent infections, major trauma, major surgery, or other diseases affecting systemic inflammatory response; 4. Peripheral vascular diseases or limb disabilities that are contraindications for remote ischemic preconditioning (RIPC).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatine kinase isoenzyme, CK-MB;High-sensitivity troponin I, Hs-cTnI;NT-proBNP;Creatinine;Interleukin-6, IL-6;High-sensitivity C-reactive protein, hs-CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital major adverse cardiovascular events, MACEs;Electrocardiogram changes;Vital signs changes; | — |
Countries
China
Contacts
Public ContactHong Zhu
Xuzhou Medical University Affiliated Hospital
Outcome results
None listed