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Exploring the Efficacy and Mechanisms of High-Precision Transcranial Direct Current Stimulation in Patients with Chronic Low Back Pain and Depressive Symptoms Based on Electroencephalogram (EEG)

Exploring the Efficacy and Mechanisms of High-Precision Transcranial Direct Current Stimulation in Patients with Chronic Low Back Pain and Depressive Symptoms Based on Electroencephalogram (EEG)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103363
Enrollment
Unknown
Registered
2025-05-28
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Low Back Pain and Depressive Symptoms

Interventions

Intervention group:HD-tDCS Intervention: HD-tDCS will be applied using the Starstim 8 device (Neuroelectrics, Spain) to the left dorsolateral prefrontal cortex (L-DLPFC, electrode position F3). Based
Sham group:Sham Stimulation Intervention: Participants will undergo a sham stimulation process, which simulates the real stimulation. The current will rise to 1mA within the first 30 seconds, then qui

Sponsors

The Sixth Affiliated Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 65 years. 2. Chronic nonspecific low back pain, with pain symptoms lasting >= 3 months, pain occurring >= 3 days per week, and a pain intensity score of >= 3 on the Numerical Rating Scale. 3. Beck Depression Inventory (BDI-II) total score > 13. 4. Voluntary participation in the study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Diagnosed with depression and requires antidepressant medication. 2. Presence of specific or potential causes for low back pain (e.g., sciatica, spinal stenosis, herniated disc, spondylolisthesis, recent vertebral fractures). 3. Presence of serious systemic or visceral diseases, including inflammatory diseases, malignant tumors, infections, or trauma. 4. Pain in other parts of the body more severe than low back pain. 5. Plans to undergo surgery within the next two months. 6. Pregnancy or in the pre-pregnancy phase. 7. Presence of contraindications for tDCS or EEG (e.g., scalp lesions).

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;—

Secondary

MeasureTime frame
Beck Depression Inventory-II;Electroencephalogram;Pressure Pain Threshold;Oswestry Disability Index;Depression Anxiety Stress Scales;Pain Catastrophizing Scale;Short Form 36;—

Countries

China

Contacts

Public ContactYuling Wang

The Sixth Affiliated Hospital, Sun Yat-sen University

wangyul@mail.sysu.edu.cn+86 130 5444 5587

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026