Esophageal cancer
Conditions
Interventions
Single arm:Radiotherapy was intensity-modulated radiotherapy PTVDT30Gy/10F/2W, concurrent with chemotherapy and immunotherapy (D22-31).
Sponsors
Yunnan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patients aged >=18 years and <=75 years with potentially resectable locally advanced esophageal cancer; 2. Radical treatment of esophageal cancer (including surgery, radiotherapy, chemotherapy and immunotherapy); 3. patients with pathologically confirmed esophageal cancer and pathological stage cT2N+ or cT3-4a any N thoracic or abdominal esophageal cancer; 4. PS score 0-2; 5. Women of childbearing age who are contraindicated to xenophobic treatment should use contraception for at least one month before screening, and commit to use contraception throughout the study period and continue for the specified time after the end of the study.
Exclusion criteria
Exclusion criteria: 1. patients with pathologically confirmed early esophageal cancer 2. pregnant or lactating women 3. patients with serious non-neoplastic medical complications, which may affect the implementation of radiotherapy 4. severe liver and kidney dysfunction or immune system diseases, and contraindications to chemotherapy and immunotherapy 5) a history of malignant tumors within the past 5 years (excluding previous lobular carcinoma in situ, skin basal cell carcinoma, skin carcinoma in situ, and cervical carcinoma in situ) 6) previous history of thoracic radiotherapy 7) had active collagen vasculopathy 8) distant metastasis confirmed by pathology or imaging 9) patients who refused radiotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate, ORR;progression free survival, PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Convert to operable rate;Pathological remission rate;Overall survival; | — |
Countries
China
Contacts
Public ContactXia Yaoxiong
Yunnan Cancer Hospital
Outcome results
None listed