None listed
Conditions
Interventions
levodopa:Oral administration of 500 mg levodopa tablets. Blood samples were taken before and 30 min, 60 min, 90 min, 120 min after treatment. Visual analogue scale (Vas) was used to assess adverse rea
oral water load + levodopa:Participants were asked to refrain from smoking and drinking alcoholic/caffeinated beverages for 12 hours prior to the trial. Take part in the test 2 hours after eating ligh
oral water load + water deprivation:After the participants underwent a water stress test, fluid intake was restricted and observed for 8-10 hours. Blood and urine samples were collected before and eve
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Healthy adults aged 18-55 years with normal drinking habits, no history of polyuria and no use of diuretics.
Exclusion criteria
Exclusion criteria: (1) history or presence of heart failure, cirrhosis or chronic alcohol consumption, nephrotic syndrome, renal failure (calculated creatinine 160 mm Hg, diastolic blood pressure > 95 mm Hg) and other serious conditions. (2) hypothyroidism or hyperthyroidism, decreased cortisol levels or Cushing's syndrome or diabetes insipidus. Be pregnant or breast-feeding. (3) drinking in the past three days or daily drinking or drinking more than three times a week in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood copeptin level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma metabolites;Blood protein; | — |
Countries
China
Contacts
Public ContactChen Shi
Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union
Outcome results
None listed